The body normally releases chemicals into the bloodstream to fight an infection.
Sepsis occurs when the body's response to these chemicals is out of balance, triggering changes that can damage multiple organ systems.
Photobiomodulation is a treatment that is based on the effects of light on damage tissues, such as lasers, light-emitting diode (LED), among others.
Photobiomodulation has been pointed out as an interesting tool for the treatment of lung diseases, as experimental studies have shown that a low level of laser therapy reduces the inflammation and oxidative stress in lung disorders 15,16,17,18,19,20
Mice where injected with a lipopolysaccharide an endotoxin which results in acute lung injury. The treatment of ALI is a clinical problem, as anti-inflammatory drugs are inefficient 3,12,13,14.
Administration of red light 660nm resulted in interference of cell mobilization into the lungs, especially the neutrophils, which exacerbated the influxes and the inflammatory activities that were damaging the lung tissue.
It is known that a high ROS is produced in the early phase of ALI, mainly by migrated neutrophils and that this leads to tissue damage, cell dysfunction and uncontrolled inflammatory responses 40,41.
Adminstration of red light blocked the cytokine-induced chemotaxis and the oxidative burst (cytokine storm)
"As a consequence, we are confident to propose that local LED treatment be a co-adjuvant, non-invasive and inexpensive approach for sepsis treatment"